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Article

A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region.

Briefings in bioinformatics - 4 May 2026

Li Ronnie Y, Su Chang, Qin Zhaohui S

Abstract excerpt

Expression quantitative trait loci (eQTLs) are regulatory variants that affect the expression level of their target genes and have significant impact on disease biology. However, eQTL mapping has been done mostly in one tissue at a time, despite the known prevalence of correlations among tissues. Multivariate analyses incorporating multiple phenotypes are available, but they emphasize linear combinations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42153321
DOI: 10.1093/bib/bbag238
PMCID: PMC13184528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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