Article

Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory R region of ABCC transporters

2021-01-29

Abstract excerpt

ATP binding cassette (ABC) proteins typically function in active transport of solutes across membranes. The ABC core structure is comprised of two transmembrane domains (TMD1 and TMD2) and two cytosolic nucleotide binding domains (NBD1 and NBD2). Some members of the C-subfamily of ABC (ABCC) proteins, including human multidrug resistance proteins (MRPs), also possess an N-terminal transmembrane domain (TMD0) that...

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Literature Corpus work: 7cd9ee43-0111-533c-9047-a2ba5bd04a38
DOI: 10.1101/2021.01.29.428621

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