Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative Regulation of the Yeast ABC Transporter Ycf1p by Phosphorylation within Its N-terminal Extension

31 Jul 2008

Abstract excerpt

The yeast vacuolar membrane protein Ycf1p and its mammalian counterpart, MRP1, belong to the ABCC subfamily of ATP-binding cassette (ABC) transporters that rid cells of toxic endogenous and xenobiotic compounds. Like most members of the ABCC subfamily, Ycf1p contains an N-terminal extension in addition to its ABC "core" domain and transports substrates in the form of glutathione conjugates. Ycf1p is subject to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Prion Diseases and Protein Misfolding
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18667437
DOI: 10.1074/jbc.m802569200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative Regulation of the Yeast ABC Transporter Ycf1p by Phosphorylation within Its N-terminal ExtensionPMID 18667437Read ↗

ABC Transporters in Saccharomyces cerevisiae and Their Interactors: New Technology Advances the Biology of the ABCC (MRP) SubfamilySemantic proximity Read ↗

Requirement of the N-terminal extension for vacuolar trafficking and transport activity of yeast Ycf1p, an ATP-binding cassette transporter.Semantic proximity Read ↗

Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249.Semantic proximity Read ↗

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.Semantic proximity Read ↗

Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transportersSemantic proximity Read ↗

Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter.Semantic proximity Read ↗

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammalsSemantic proximity Read ↗

The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion.Semantic proximity Read ↗

Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory R region of ABCC transportersSemantic proximity Read ↗

A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity.Semantic proximity Read ↗

Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.Semantic proximity Read ↗

The yeast CLC protein counteracts vesicular acidification during iron starvation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.