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Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters

21 May 2021

Abstract excerpt

channel, little is known about the structure of TMD0 in monomeric ABC transporters. Here, we present the structure of yeast cadmium factor 1 protein (Ycf1p), a homolog of human MRP1, determined by electron cryo-microscopy (cryo-EM). A comparison of Ycf1p, SUR1, and a structure of MRP1 that showed TMD0 at low resolution demonstrates that TMD0 can adopt different orientations relative to the ABC core, including a...

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PMID: 34021087
DOI: 10.1073/pnas.2025853118

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