Article
Activation of Atg1 kinase in autophagy by regulated phosphorylation.
Autophagy - 1 Nov 2010
Kijanska Monika, Dohnal Ilse, Reiter Wolfgang, Kaspar Susanne, Stoffel Ingrid, Ammerer Gustav, Kraft Claudine, Peter Matthias
Abstract excerpt
Autophagy is a highly regulated trafficking pathway that leads to selective degradation of cellular constituents such as protein aggregates and excessive and damaged organelles. Atg1 is an essential part of the core autophagic machinery, which triggers induction of autophagy and the Cvt pathway. Although changes in Atg1 phosphorylation and complex formation are thought to regulate its function, the mechanism of...
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