Article

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

2021-08-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure inflames skin. Beneficial effects of anifrolumab (anti-interferon α/breceptor (anti-IFNAR)) on lupus skin disease support a pathogenic role for IFN-I, but mechanistic understanding is limited. We have shown that Langerhans cell (LC)...

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Literature Corpus work: 7c621e36-f56c-5976-a6c6-563f6ba3ddc5
DOI: 10.1101/2021.08.18.456792

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