Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity

15 Aug 2018

Abstract excerpt

Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus and other autoimmune and dermatologic conditions, but the mechanistic underpinnings are poorly understood. We identify a Langerhans cell (LC)-keratinocyte axis that limits UVR-induced keratinocyte apoptosis and skin injury via keratinocyte epidermal growth factor receptor (EGFR) stimulation. We show that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Immunotherapy and Immune Responses
Share to Skin Protection and Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30111646
DOI: 10.1126/scitranslmed.aap9527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivityPMID 30111646Read ↗

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupusSemantic proximity Read ↗

Exploring the Correlation Between UVB Sensitivity and SLE Activity: Insights into UVB-Driven Pathogenesis in Lupus ErythematosusSemantic proximity Read ↗

Pathophysiology of cutaneous lupus erythematosusSemantic proximity Read ↗

Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) responseSemantic proximity Read ↗

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based PhototherapySemantic proximity Read ↗

Chronic UV radiation-induced RORγt+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion.Semantic proximity Read ↗

Langerhans cells and skin immune diseasesSemantic proximity Read ↗

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8Semantic proximity Read ↗

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9 <sup>+</sup> Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive AutoimmunitySemantic proximity Read ↗

Langerhans Cells: Sensing the Environment in Health and Disease.Semantic proximity Read ↗

Epidermal ablation of Dlx3 is linked to IL-17–associated skin inflammationSemantic proximity Read ↗

Autophagy: Guardian of Skin BarrierSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.