Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology

23 Jan 2009

Abstract excerpt

In this work we showed that genotype-related patterns of hexosaminidase activity, isoenzyme composition, gene expression and ganglioside metabolism observed during embryonic and postnatal brain development are recapitulated during the progressive stages of neural precursor cell (NPC) differentiation to mature glia and neurons in vitro. Further, by comparing NPCs and their differentiated progeny established from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Glycosylation and Glycoproteins Research
Share to Lysosomal Storage Disorders Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19166507
DOI: 10.1111/j.1471-4159.2009.05919.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathologyPMID 19166507Read ↗

Plasma Membrane Remodelling in GM2 Gangliosidoses Drives Synaptic DysfunctionSemantic proximity Read ↗

Genetics and Therapies for GM2 Gangliosidosis.Semantic proximity Read ↗

GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies.Semantic proximity Read ↗

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.Semantic proximity Read ↗

GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects and Current TherapiesSemantic proximity Read ↗

Gangliosidoses.Semantic proximity Read ↗

Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.Semantic proximity Read ↗

Mice Doubly-Deficient in Lysosomal Hexosaminidase A and Neuraminidase 4 Show Epileptic Crises and Rapid Neuronal LossSemantic proximity Read ↗

Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosisSemantic proximity Read ↗

Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis.Semantic proximity Read ↗

Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.Semantic proximity Read ↗

An inducible mouse model of late onset Tay-Sachs disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.