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Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model

16 Mar 2023

Abstract excerpt

Tay-Sachs disease is a lethal lysosomal storage disorder caused by mutations in the HexA gene encoding the α subunit of the lysosomal β-hexosaminidase enzyme (HEXA). Abnormal GM2 ganglioside accumulation causes progressive deterioration in the central nervous system in Tay-Sachs patients. Hexa-/- mouse model failed to display abnormal phenotype. Recently, our group generated Hexa-/-Neu3-/- mouse showed severe...

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PMID: 36928510
DOI: 10.1371/journal.pone.0280650

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Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse modelPMID 36928510Read ↗

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