Article

Combined Treatment of Ketogenic Diet and Propagermanium Reduces Neuroinflammation in Tay-Sachs Disease Mouse Model

2024-02-05

Abstract excerpt

<title>Abstract</title> <p>Tay-Sachs disease is a rare lysosomal storage disorder caused by β-hexosaminidase A enzyme deficiency causing abnormal GM2 ganglioside accumulation in the central nervous system. GM2 accumulation triggers chronic neuroinflammation due to neurodegeneration-based astrogliosis and macrophage activity with the increased expression level of Ccl2 in the cortex of a recently generated Tay-Sach...

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Literature Corpus work: 57d42c08-f443-5d35-9554-20a36c318bd5
DOI: 10.21203/rs.3.rs-3899681/v1

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