Article

Adaptive disorder as the hallmark of nanobodies antigen-binding loops

2025-10-10

Abstract excerpt

Nanobodies are antigen-binding proteins of great interest as diagnostics and therapeutics. Accurate and fast characterization of their complementarity-determining regions (CDRs) is crucial to uncover the principles guiding their design. Yet, this task remains challenging, as random recombination and somatic mutations generate highly diverse CDR sequences that escape motif-based or structure-prediction approaches c...

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Literature Corpus work: 5e17a4ff-905b-58ca-9954-af7ad0fb9911
DOI: 10.1101/2025.10.10.681624

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