Article
In vivo analysis of growth hormone receptor signaling domains and their associated transcripts.
Molecular and cellular biology - 1 Jan 2005
Rowland Jennifer E, Lichanska Agnieszka M, Kerr Linda M, White Mary, d'Aniello Elisabetta M, Maher Sheryl L, Brown Richard, Teasdale Rohan D, Noakes Peter G, Waters Michael J
Abstract excerpt
The growth hormone receptor (GHR) is a critical regulator of postnatal growth and metabolism. However, the GHR signaling domains and pathways that regulate these processes in vivo are not defined. We report the first knock-in mouse models with deletions of specific domains of the receptor that are required for its in vivo actions. Mice expressing truncations at residue m569 (plus Y539/545-F) and at residue m391...
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