Article
microRNAs in vertebrate physiology and human disease.
Annual review of genomics and human genetics - 1 Jan 2007
Chang Tsung-Cheng, Mendell Joshua T
Abstract excerpt
Over the past five years, the importance of a diverse class of 18-24 nucleotide RNA molecules, known as microRNAs (miRNAs) has increasingly been recognized. These highly conserved RNAs regulate the stability and translational efficiency of complementary target messenger RNAs. The human genome is now predicted to encode nearly 1,000 miRNAs that likely regulate at least one third of all human transcripts. Despite...
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