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Article

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.

Journal of neurochemistry - 1 Mar 2010

Rosi Maria Cristina, Luccarini Ilaria, Grossi Cristina, Fiorentini Anna, Spillantini Maria Grazia, Prisco Antonella, Scali Carla, Gianfriddo Marco, Caricasole Andrea, Terstappen Georg C, Casamenti Fiorella

Abstract excerpt

To investigate the role of the Wnt inhibitor Dickkopf-1 (DKK-1) in the pathophysiology of neurodegenerative diseases, we analysed DKK-1 expression and localization in transgenic mouse models expressing familial Alzheimer's disease mutations and a frontotemporal dementia mutation. A significant increase of DKK-1 expression was found in the diseased brain areas of all transgenic lines, where it co-localized with...

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PMID: 20050968
DOI: 10.1111/j.1471-4159.2009.06566.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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