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Refined Procedure to Purify and Sequence Circulating Cell-Free DNA in Prostate Cancer

18 Jun 2025

Abstract excerpt

Cell-free DNA (cfDNA), a fragmented DNA circulating in blood, is a promising biomarker for cancer diagnosis and monitoring. Standardization of cfDNA isolation to enhance the sensitivity of molecular analyses in prostate cancer (PCa) is required. Towards this goal, we optimized existing methods to obtain a high quantity and quality of cfDNA from low volumes of plasma. The protocol was applied to samples from...

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PMID: 40565311
DOI: 10.3390/ijms26125839

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