Article
Pathology methods for the evaluation of embryonic and perinatal developmental defects and lethality in genetically engineered mice.
Veterinary pathology - 1 Jan 2012
Ward J M, Elmore S A, Foley J F
Abstract excerpt
The normal embryonic development of organs and other tissues in mice and all species is preprogrammed by genes. Inactivation of a gene involved in any stage of normal embryonic development can have severe consequences leading to embryonic or postnatal developmental defects and lethality. Pathology methods are reviewed for evaluating normal and abnormal placenta and embryo, especially after E12.5. These methods...
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