Back to search

Article

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

2019-08-07

Abstract excerpt

Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene transcription. We developed a PI polyamide targeting human TGF-b1 (hTGF-b1). To develop PI polyamide targeting hTGF-b1 (Polyamide) as a practical medicine for progressive renal diseases, we examined the effects of Polyamide in two common marmoset models of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7b5b3f2b-461f-5df1-bc7c-efb6aa86daaa
DOI
10.20944/preprints201908.0090.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common MarmosetDOI 10.20944/preprints201908.0090.v1
Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells.Semantic proximity
Nucleic Acid-based Small Molecules as Targeted Transcription Therapeutics for ImmunoregulationSemantic proximity
<i>OFF</i> -Target Effects of Mycophenolic Acid on BK Polyomavirus Replication in Primary Human Renal Proximal Tubular Epithelial CellsSemantic proximity
N <sup>1</sup> -methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytesSemantic proximity
Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathySemantic proximity
Albumin-binding RNAi Conjugate for Carrier Free Treatment of ArthritisSemantic proximity
DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathySemantic proximity
Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents.Semantic proximity
Arginase I mRNA therapy - a novel approach to rescue arginase 1 enzyme deficiency.Semantic proximity
Short report of potential Myelinogenesis effects of taper up-off of opium tincture in rodent model of multiple sclerosisSemantic proximity
[Correlation between TGF-B gene promoter-509C/T polymorphism and IgA nephropathy in core families in Guangxi Zhuang Autonomous Region and the therapeutic effect of dendrobium].Semantic proximity
Select a neighboring publication to make it the new centre.