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Article

Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells.

Molecules (Basel, Switzerland) - 23 Jun 2020

Takagi Keiko, Midorikawa Yutaka, Takayama Tadatoshi, Abe Hayato, Fujiwara Kyoko, Soma Masayoshi, Nagase Hiroki, Miki Toshio, Fukuda Noboru

Abstract excerpt

Synthetic pyrrole-imidazole (PI) polyamides bind to the minor groove of double-helical DNA with high affinity and specificity, and inhibit the transcription of corresponding genes. In liver cancer, transforming growth factor (TGF)-β expression is correlated with tumor grade, and high-grade liver cancer tissues express epithelial-mesenchymal transition markers. TGF-β1 was reported to be involved in cancer...

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PMID: 32585841
DOI: 10.3390/molecules25122883
PMCID: PMC7356887

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