Article

Chondrosarcoma Organoids Reveal Targetable SHH Pathway Activation via PTCH1 Alterations

2025-11-14

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose</bold> Chondrosarcoma is the second most common malignant bone tumor, characterized by the production of cartilaginous matrix and a high degree of resistance to conventional therapies such as chemotherapy and radiotherapy. Effective treatment options remain limited, highlighting the urgent need for preclinical models to explore novel therapeutic approaches. This study a...

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Literature Corpus work: 24e1dde8-0fd4-5f06-ba27-647751b24b56
DOI: 10.21203/rs.3.rs-7826834/v1

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