Article

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host

2024-05-06

Abstract excerpt

<h4>Summary</h4> Glioblastoma (GBM) is the most common primary brain tumor in adults with a poor prognosis despite aggressive therapy. A recent, retrospective clinical study found that administering Temozolomide in the morning increased patient overall survival by 6 months compared to evening. Here, we tested the hypothesis that daily host signaling regulates tumor growth and synchronizes circadian rhythms in GBM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b158e8a-8431-5f3a-ba63-acdc65faa740
DOI: 10.1101/2024.05.03.592418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the hostDOI 10.1101/2024.05.03.592418Read

Circadian regulation of <i>MGMT</i> expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastomaSemantic proximity Read

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor MicroenvironmentSemantic proximity Read

Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I TrialsSemantic proximity Read

IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87‑MG cells.Semantic proximity Read

Enhancing circadian clock function in cancer cells inhibits tumor growthSemantic proximity Read

Advancing clinical response against glioblastoma: Evaluating SHP1705 CRY2 activator efficacy in preclinical models and safety in phase I trialsSemantic proximity Read

Circadian Gene <em>cry</em> Controls Glioblastoma Tumorigenesis through Modulation of <em>myc</em> ExpressionSemantic proximity Read

Differential expression of the circadian clock network correlates with tumour progression in gliomas.Semantic proximity Read

Circadian genesPer1andPer2increase radiosensitivity of gliomain vivoSemantic proximity Read

Protective effects of testosterone replacement therapy on brain tumor outcomes: the Mayo Clinic ExperienceSemantic proximity Read

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasivenessSemantic proximity Read

Circadian Timing in Cancer TreatmentsSemantic proximity Read