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Enhancing circadian clock function in cancer cells inhibits tumor growth

14 Feb 2017

Abstract excerpt

BACKGROUND: Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, we compared growth and cell cycle events of B16 melanoma cells and tumors with either a functional or dysfunctional clock. RESULTS: We found that clock genes were suppressed in B16 cells and...

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PMID: 28196531
DOI: 10.1186/s12915-017-0349-7

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