Article

Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials

2024-09-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> It has been reported that circadian clock components, Brain and Muscle ARNT-Like 1 (BMAL1) and Circadian Locomotor Output Cycles Kaput (CLOCK), are uniquely essential for glioblastoma (GBM) stem cell (GSC) biology and survival. Consequently, we developed a novel Cryptochrome (CRY) activator SHP1705, which inhibits BMAL1-CLOCK transcriptional activity. <h4>Methods</h4> We an...

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Literature Corpus work: f9aa41f0-11f0-5dc8-bed4-57ac671f7b1f
DOI: 10.1101/2024.09.17.613520

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