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Circadian Timing in Cancer Treatments

8 Jan 2010

Abstract excerpt

The circadian timing system is composed of molecular clocks, which drive 24-h changes in xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and angiogenesis. The cellular circadian clocks are coordinated by endogenous physiological rhythms, so that they tick in synchrony in the host tissues that can be damaged by anticancer agents. As a result, circadian timing can modify 2- to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20055686
DOI: 10.1146/annurev.pharmtox.48.113006.094626

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