Article
IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87‑MG cells.
Molecular medicine reports - 1 May 2021
Gao Yongying, Wu Yanwei, Zhang Ningmei, Yuan Hongmei, Wang Fei, Xu Hui, Yu Jiaxiang, Ma Jie, Hou Shaozhang, Cao Xiangmei
Abstract excerpt
Isocitrate dehydrogenase1 (IDH1) mutation is the most important genetic change in glioma. The most common IDH1 mutation results in the amino acid substitution of arginine 132 (Arg/R132), which is located at the active site of the enzyme. IDH1 Arg132His (R132H) mutation can reduce the proliferative rate of glioma cells. Numerous diseases follow circadian rhythms, and there is growing evidence that circadian...
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