Article

EPRS Regulates Proline-rich Pro-fibrotic Protein Synthesis during Cardiac Fibrosis

2019-09-20

Abstract excerpt

<h4>Rationale</h4> Increased protein synthesis of pro-fibrotic genes is a common feature of cardiac fibrosis, a major manifestation of heart failure. Despite this important observation, critical factors and molecular mechanisms for translational control of pro-fibrotic genes during cardiac fibrosis remain unclear. <h4>Objective</h4> This study aimed to test the hypothesis that cardiac stress-induced expression o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7aa03cfd-5092-5376-8cd0-8b29506f0bd9
DOI: 10.1101/777490

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

EPRS Regulates Proline-rich Pro-fibrotic Protein Synthesis during Cardiac FibrosisDOI 10.1101/777490Read

Translational control of cardiac fibrosisSemantic proximity Read

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasisSemantic proximity Read

Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failureSemantic proximity Read

ER Stress-Response Signaling Regulates Chamber-Specific Growth between Right and Left Ventricles during Postnatal DevelopmentSemantic proximity Read

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac SplicingSemantic proximity Read

Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failureSemantic proximity Read

A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart FailureSemantic proximity Read

Translational regulation shapes the molecular landscape of complex disease phenotypes.Semantic proximity Read

Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in MiceSemantic proximity Read

skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart FailureSemantic proximity Read

Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and FibrosisSemantic proximity Read

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosisSemantic proximity Read