Article

Human cerebral tissues created via active cellular reaggregation produce functionally interconnected 3D neuronal network to mimic pathological circuit disturbance

2020-06-12

Abstract excerpt

Various characteristics of a developing central nervous system, including sensory input-output 1,2 , neuronal migration 3,4 , and regionalization 3,5 , have been recapitulated through recent advances in the culture of brain organoids. These organoids can model the fundamental processes in brain development and disease. A remaining critical challenge, however, is to achieve complex neuronal networks with functio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a6d09ca-ebc3-594d-9021-00092f22b986
DOI: 10.1101/2020.06.11.144832

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cerebral tissues created via active cellular reaggregation produce functionally interconnected 3D neuronal network to mimic pathological circuit disturbanceDOI 10.1101/2020.06.11.144832Read

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in EpileptogenesisSemantic proximity Read

In vitro reconstitution of hippocampal cell assembliesSemantic proximity Read

Brain organoid-on-a-chip to create multiple domains in forebrain organoidsSemantic proximity Read

Assembloid model to study loop circuits of the human nervous systemSemantic proximity Read

Mouse brain organoids model <i>in vivo</i> neurodevelopment and function and capture differences to humanSemantic proximity Read

Modeling neurological disorders using brain organoids.Semantic proximity Read

Controllable Fusion of Human Brain Organoids Using AcoustofluidicsSemantic proximity Read

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus InfectionSemantic proximity Read

Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (Part 1).Semantic proximity Read

Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and MemorySemantic proximity Read

Self-Organizing 3D Human Choroid Plexus-Ventricle-Cortical OrganoidsSemantic proximity Read

Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell linesSemantic proximity Read