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Article

A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance

1 Mar 2025

Abstract excerpt

Clostridioides difficile , a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but the precise mechanisms are not fully described. Through a meta-analysis of 12 human studies, we designed a synthetic fecal microbiota transplant (sFMT1) by reconstructing microbial networks negatively associated with C. difficile colonization. This lab-built 37-strain consortium formed a functional...

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PMID: 40037353
DOI: 10.1016/j.chom.2025.02.007

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