Article

Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

2023-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant skipping of coding exons in CD19 and CD22 compromises responses to immunotherapy for B-cell malignancies. Here, we show that the MS4A1 gene encoding human CD20 also produces several mRNA isoforms with distinct 5’ untranslated regions (5’-UTR). Four variants (V1-4) were detectable by RNA-seq in distinct stages of normal B-cell differentiation and B-lymphoid malignancies, with V1 and V3...

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Literature Corpus work: 7a31393e-5613-53b3-88b1-14130f3a9b28
DOI: 10.1101/2023.02.19.529123

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