Article

Sequential Antigen-loss and Branching Evolution in Lymphoma after Anti-CD19 and Anti-CD20 Targeted T Cell Redirecting Immunotherapy

2023-04-07

Abstract excerpt

<title>Abstract</title> <p>CD19 CAR T cells and CD20 targeting T cell engaging bispecific antibodies have been approved in B-cell Non-Hodgkin lymphoma lately, heralding a new clinical setting where patients are treated with both approaches, sequentially. The aim of our study was to investigate the selective pressure of CD19 and CD20 directed therapy on the clonal architecture in lymphoma. Using a broad analytical...

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Literature Corpus work: 663079cf-1ce8-5b7b-a60e-45bbbf21119f
DOI: 10.21203/rs.3.rs-2762036/v1

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