Article

Identification of enzymes that are required for Rhodoquinone-dependent metabolism as targets for new species-specific inhibitors

2021-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Soil transmitted helminths (STHs) are major human pathogens that infect over a billion people. Resistance to current anthelmintics is rising and new drugs are needed. Here we combine multiple approaches to find druggable targets that are essential for RQ-dependent metabolism, an unusual form of anaerobic metabolism which STHs need to survive in their host. We identified 25 genes predicted to act...

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Literature Corpus work: 797b9cc1-fee3-5e05-985a-e03fdc57b68d
DOI: 10.1101/2021.03.24.436840

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