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Matrine and Oxymatrine: evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test).

Mutagenesis - 8 Feb 2024

Fischer Benjamin Christian, Musengi Yemurai, König Jeannette, Sachse Benjamin, Hessel-Pras Stefanie, Schäfer Bernd, Kneuer Carsten, Herrmann Kristin

Abstract excerpt

The quinolizidine alkaloids matrine and its N-oxide oxymatrine occur in plants of the genus Sophora. Recently, matrine was sporadically detected in liquorice products. Morphological similarity of the liquorice plant Glycyrrhiza glabra with Sophora species and resulting confusion during harvesting may explain this contamination, but use of matrine as pesticide has also been reported. The detection of matrine in...

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PMID: 37877816
DOI: 10.1093/mutage/gead032
PMCID: PMC10851102

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