Article

Investigation of βAR-dependent cAMP signalling in induced pluripotent stem cell-derived cardiomyocytes

2021-01-01

Abstract excerpt

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great potential for drug testing, cell therapy, and as models of genetic aberrations such as mutations, polymorphisms etc. However, current differentiation protocols do not produce cells which are as mature, both structurally and functionally, as adult cardiomyocytes. In mature cells, β-adrenergic (βAR) pathway regulates the rate and stren...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79791b50-b85b-5e3b-8102-c50bad18c14d
DOI: 10.25560/88323

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of βAR-dependent cAMP signalling in induced pluripotent stem cell-derived cardiomyocytesDOI 10.25560/88323Read

Evaluating and comparing the signalling and functional landscape of iPSC- CMs derived from patients with dilated cardiomyopathySemantic proximity Read

Mitigation of Stress-induced Structural Remodeling and Functional Deficiency in iPSC-CMs with PLN R9C Mutation by Promoting AutophagySemantic proximity Read

Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonistsSemantic proximity Read

Electrophysiological phenotypes in iPSC-CMs from early repolarization syndrome with DPP6 (c.2240T > C/p.L747P) mutationSemantic proximity Read

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived CardiomyocytesSemantic proximity Read

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.Semantic proximity Read

Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytesSemantic proximity Read

In vivo model with targeted cAMP biosensor reveals changes in receptor–microdomain communication in cardiac diseaseSemantic proximity Read

Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4Semantic proximity Read

Calcium Imaging in Pluripotent Stem Cell-Derived Cardiac Myocytes.Semantic proximity Read

Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experimentsSemantic proximity Read

Pharmacogenomics of β-adrenergic receptor physiology and response to β-blockade.Semantic proximity Read