Article

The role of Fragile X in the control of vertebrate spinal cord networks

2026-02-09

Abstract excerpt

<h4>Summary</h4> Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and the leading monogenic cause of autism, resulting from mutations in the Fmr1 gene. While extensive research points to widespread circuit hyperexcitability across cortical and subcortical circuits, the contribution of the spinal cord circuits in the motor phenotypes associated with FXS remains largely unexpl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79690c69-af14-54cc-9c77-c1490deaaa90
DOI: 10.64898/2026.02.06.704392

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of Fragile X in the control of vertebrate spinal cord networksDOI 10.64898/2026.02.06.704392Read

Fmrp regulates neuronal balance in embryonic motor circuit formationSemantic proximity Read

Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndromeSemantic proximity Read

Spontaneous motor-behavior abnormalities in two Drosophila models of neurodevelopmental disorders.Semantic proximity Read

Anatomical and functional analysis of the corticospinal tract in an FRDA mouse modelSemantic proximity Read

Synchronicity in zebrafish locomotive circuit development mediated by electrical pacemaker interneuronsSemantic proximity Read

Homeostatic Inhibitory Control of Cortical Hyperexcitability in Fragile X SyndromeSemantic proximity Read

Functional Contribution of Mesencephalic Locomotor Region Nuclei to Locomotor Recovery After Spinal Cord InjurySemantic proximity Read

Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic functionSemantic proximity Read

Transcriptional dysregulation and impaired neuronal activity in <i>FMR1</i> knock-out and Fragile X patients’ iPSC-derived modelsSemantic proximity Read

Fragile X Mental Retardation Protein (FMRP) expression in human nociceptor axons of the spinal dorsal horn— Implications for RNA targeting and localized translationSemantic proximity Read

Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome.Semantic proximity Read

Pathophysiology of Dyt1 dystonia is mediated by spinal cord dysfunctionSemantic proximity Read