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Artemisinin resistant <i>kelch13</i> R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria control

2025-06-23

Abstract excerpt

The rise of antimalarial drug-resistant Plasmodium falciparum poses a major threat to malaria treatment, control, and elimination efforts. Mutations in the kelch13 ( k13 ) gene confer artemisinin partial resistance (ART-R), compromising the efficacy of combination therapies. In the Horn of Africa, the validated mutation k13 R622I has rapidly emerged in parallel with other mutations elsewhere in Eastern Africa....

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Literature Corpus work
28b2a838-3995-5491-b027-5b9d6da95ae1
DOI
10.1101/2025.06.23.25330019
Open publication

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Artemisinin resistant <i>kelch13</i> R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria controlDOI 10.1101/2025.06.23.25330019
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