Article

Forced Intracellular Degradation of Xenoantigens: A Novel Modality for Cell-Based Cancer Immunotherapy

2023-11-28

Abstract excerpt

<title>Abstract</title> <p>Background: Antigen presentation is crucial in fighting cancer and infectious diseases. This process is however dependent on proteasomal degradation of captured or intracellular antigens. Given the recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron seq...

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Literature Corpus work: 78ead143-1c24-5467-a8dc-771d58acb34c
DOI: 10.21203/rs.3.rs-3545973/v1

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