Article

Partial loss of CFIm25 causes aberrant alternative polyadenylation and learning deficits

2019-08-14

Abstract excerpt

<h4>ABSTRACT</h4> We previously showed that NUDT21 -spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21 +/- mice to mimic the human state of decreased expression. We found that although these mice have 50% reduced N...

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Literature Corpus work: 78e9c784-21af-5bab-8943-c8d9ec66356c
DOI: 10.1101/735597

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