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The first clinical validation of whole-genome screening on standard trophectoderm biopsies of preimplantation embryos

11 Jan 2024

Abstract excerpt

Objective To validate the performance of our laboratory-developed whole-genome screening assay within clinical preimplantation genetic testing environments. Design Perform a laboratory-developed whole-genome assay on both cell lines and trophectoderm biopsies, subsequently employing the next-generation sequencing procedure to reach a sequencing depth of 30X. Adhere to the Genome Analysis Toolkit best practices...

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PMID: 38524212
DOI: 10.1016/j.xfre.2024.01.001

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