Article
Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.
Molecular oncology - 1 Apr 2017
Joshi Jugal Bharat, Patel Divya, Morton Derrick J, Sharma Pankaj, Zou Jin, Hewa Bostanthirige Dhanushka, Gorantla Yamini, Nagappan Peri, Komaragiri Shravan Kumar, Sivils Jeffrey C, Xie Huan, Palaniappan Ravi, Wang Guangdi, Cox Marc B, Chaudhary Jaideep
Abstract excerpt
Castration-resistant prostate cancer (CRPC) is the emergence of prostate cancer cells that have adapted to the androgen-depleted environment of the prostate. In recent years, targeting multiple chaperones and co-chaperones (e.g., Hsp27, FKBP52) that promote androgen receptor (AR) signaling and/or novel AR regulatory mechanisms have emerged as promising alternative treatments for CRPC. We have shown that...
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