Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB

Abstract excerpt

Mycobacterium tuberculosis uses its ESX-1 system to secrete EsxA and EspB into a host to cause disease. We show that EspK, a protein whose role in the ESX-1 machinery was thought to be nonessential, is needed by M. tuberculosis for optimal EsxA and EspB secretion. Culturing EspK-deficient M. tuberculosis with detergents alleviates EsxA but not EspB secretion defects. We also show that EspK, which is exported by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Infectious Diseases and Tuberculosis
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology