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Article

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype

2025-07-11

Abstract excerpt

Src homology 3 (SH3) proteins regulate numerous fibroproliferative pathophenotypes including pulmonary arterial hypertension (PAH) but are challenging to target therapeutically. We innovated a peptidomimetic that occupies the canonical focal adhesion kinase (FAK) binding site on the SH3 domain of the neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) protein, a pro-PAH regulator. Peptidomime...

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Identifiers and source

Literature Corpus work
78c6ff3a-a8a7-5330-93ad-4172cdcde0b7
DOI
10.1101/2025.07.10.663547
Open publication

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Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial PhenotypeDOI 10.1101/2025.07.10.663547
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