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AcrAB-TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism

7 Jun 2023

Abstract excerpt

Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the development of new therapeutic agents against antibiotic resistance is in urgent demand, this has presented a great challenge, especially for Gram-negative bacteria that have inherent drug-resistance mediated by impermeable outer membranes and multidrug efflux pumps that actively extrude various drugs from the bacteria....

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Share to Antibiotic Resistance in Bacteria
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PMID: 37254571
DOI: 10.5483/bmbrep.2023-0070

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