Article
Evidence for sexual antagonism and antagonistic pleiotropy in the maintenance of late onset Alzheimer’s disease alleles
2026-02-27
Abstract excerpt
Trade-offs form a key constraint in many aspects of organismal evolution, though they may help maintain genetic diversity. Late-onset Alzheimer’s disease (LOAD) shows features in common with the male-female health survival paradox: females suffer from higher prevalence and risk, as well as faster rates of cognitive decline while males suffer higher mortality. Though antagonistic pleiotropy could explain the tenden...
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Identifiers and source
- Literature Corpus work
- 785dcd17-4f26-59a8-9e5e-72009758e694
- DOI
- 10.64898/2026.02.26.26347171