Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reassessing neurodegenerative disease: immune protection pathways and antagonistic pleiotropy.

Trends in neurosciences - 1 Oct 2021

Provenzano Francesca, Deleidi Michela

Abstract excerpt

The antagonistic pleiotropy (AP) theory posits that adaptive evolutionary changes, which facilitate reproduction and individual fitness early in life, can enhance detrimental aging-related processes. Several genes associated with human brain diseases play a protective role in infection, suggesting the relevance of AP in the context of brain aging and neurodegeneration. Relatedly, genetic variants that confer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Biological Evolution
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurodegenerative Diseases

Share to Phenotype

Source

Identifiers

PMID: 34284880
DOI: 10.1016/j.tins.2021.06.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reassessing neurodegenerative disease: immune protection pathways and antagonistic pleiotropy.PMID 34284880Read ↗

Antagonistic Pleiotropy in Human Disease.Semantic proximity Read ↗

The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and RecommendationsSemantic proximity Read ↗

Evidence for sexual antagonism and antagonistic pleiotropy in the maintenance of late onset Alzheimer’s disease allelesSemantic proximity Read ↗

Signatures of selection in pleiotropic genes involved in insect neuronal and immune systemsSemantic proximity Read ↗

Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutritionSemantic proximity Read ↗

Is antagonistic pleiotropy ubiquitous in aging biology?Semantic proximity Read ↗

Epistasis in the risk of human neuropsychiatric disease.Semantic proximity Read ↗

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseasesSemantic proximity Read ↗

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles.Semantic proximity Read ↗

Associations of chronic inflammatory diseases with brain health: a prospective cohort studySemantic proximity Read ↗

Aging, antagonistic pleiotropy and fibrotic diseaseSemantic proximity Read ↗

More evidence for widespread antagonistic pleiotropy in polymorphic disease allelesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.