Article

Identification of a novel immune checkpoint molecule V‐set immunoglobulin domain‐containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma

2022-05-13

Abstract excerpt

<h4>Background: </h4> Checkpoint-based immunotherapy has failed to elicit responses in the majority of patients with pancreatic cancer. In our study, we aimed to identify the role of a novel immune checkpoint molecule V-set Ig domain-containing 4 (VSIG4) in pancreatic ductal adenocarcinoma (PDAC). Methods Online datasets and tissue microarray (TMA) were utilized to analyze the expression level of VSIG4 and its co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 784b33e0-dcb1-58d8-8ce8-415e0e47bc74
DOI: 10.21203/rs.3.rs-1640985/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a novel immune checkpoint molecule V‐set immunoglobulin domain‐containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinomaDOI 10.21203/rs.3.rs-1640985/v1Read

Comprehensive Genomic Analysis of the Prognostic and Immunological Characteristics of Tertiary Lymphoid structures and CD8+ T-cells in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Viewing the immune checkpoint VISTA: landscape and outcomes across cancersSemantic proximity Read

A comprehensive transcriptional signature in pancreatic ductal adenocarcinoma reveals new insights into the immune and desmoplastic microenvironmentSemantic proximity Read

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-SeqSemantic proximity Read

Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Metaanalysis of transcriptional subtypesSemantic proximity Read

A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.Semantic proximity Read

Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical TargetsSemantic proximity Read

Mechanism of ASIC4 in Regulating MHC-I-Mediated Immune Evasion in Pancreatic CancerSemantic proximity Read

High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development.Semantic proximity Read

Comprehensive Analysis of Clinical Prognosis and Molecular Immune Characterization of TPM4 in Pancreatic CancerSemantic proximity Read

B4GALT5 inhibits CD8+ T-cell response by downregulating MHC-I level through ERAD pathway in PDACSemantic proximity Read