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Article

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis.

CNS drugs - 1 Mar 2016

Moujalled Diane, White Anthony R

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset, neurodegenerative disease characterized by the degeneration of upper and lower motor neurons. Over recent years, numerous genes ha ve been identified that promote disease pathology, including SOD1, TARDBP, and the expanded hexanucleotide repeat (GGGGCC) within C9ORF72. However, despite these major advances in identifying genes contributing to ALS...

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Identifiers

PMID: 26895253
DOI: 10.1007/s40263-016-0317-8

Genes

SOD1
TARDBP

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