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Genomic alterations in persistently infecting oncolytic Newcastle disease virus reveal mechanisms of viral persistence in bladder cancer cells

2025-05-10

Abstract excerpt

<h4>Abstracts</h4> Newcastle disease virus (NDV) is a promising oncolytic agent with a non-segmented, negative-sense single-stranded RNA (ssRNA) genome of approximately 15 kb. While NDV selectively replicates in and lyses a wide range of human cancer cells, a subset of these cells develop persistent infections, potentially compromising the therapeutic efficacy of NDV-based treatments. To investigate the molecular...

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Literature Corpus work
78270e8b-8732-5757-b92b-83d1f60cb932
DOI
10.1101/2025.05.06.652422
Open publication

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Genomic alterations in persistently infecting oncolytic Newcastle disease virus reveal mechanisms of viral persistence in bladder cancer cellsDOI 10.1101/2025.05.06.652422
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