O'nyong-nyong virus adaptive mutations in non-structural protein 1 and 3 enhance RNA replication and overcome FHL1 requirement.

doi:10.1080/22221751.2026.2721742

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Article

O'nyong-nyong virus adaptive mutations in non-structural protein 1 and 3 enhance RNA replication and overcome FHL1 requirement.

Emerging microbes & infections - 1 Dec 2026

Hick Tessy A H, Cirksena Karsten, Evander Magnus, Gerold Gisa

Abstract excerpt

Arthritogenic alphaviruses, like o'nyong-nyong virus (ONNV), cause debilitating musculoskeletal diseases and are geographically expanding. To predict their emergence, we seek to better understand evolutionary mechanisms that enable changes in virus tropism. Here, we identify adaptive mutations in the ONNV non-structural proteins (nsPs) that arose during cellular serial passaging and enabled ONNV to infect...

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Share to Alphavirus
Share to Cell Line, Tumor
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LIM Domain Proteins

Share to Muscle Proteins

Share to RNA, Viral

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Identifiers

PMID: 42616815
DOI: 10.1080/22221751.2026.2721742
PMCID: PMC13528125

Genes

FHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.