Article

A long non-coding RNA Leat1 mediates the hormone responsiveness of EfnB2 during male urogenital development

2023-07-03

Abstract excerpt

<title>Abstract</title> <p>The novel long non-coding RNA (lncRNA) Leat1 is extraordinarily conserved in both its location (syntenic with EfnB2, an essential gene in anogenital patterning) and sequence. Here we show that Leat1 is upregulated following the testosterone surge from the developing testis and directly interacts with EfnB2, positively regulating its expression. Leat1 expression is suppressed by estrogen...

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Literature Corpus work: 7804dec2-88dc-5f01-bd2b-04904abb48e6
DOI: 10.21203/rs.3.rs-3098271/v1

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