Article
Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype.
American journal of respiratory and critical care medicine - 1 Apr 2021
Rago Daniela, Pedersen Casper-Emil T, Huang Mengna, Kelly Rachel S, Gürdeniz Gözde, Brustad Nicklas, Knihtilä Hanna, Lee-Sarwar Kathleen A, Morin Andréanne, Rasmussen Morten A, Stokholm Jakob, Bønnelykke Klaus, Litonjua Augusto A, Wheelock Craig E, Weiss Scott T, Lasky-Su Jessica, Bisgaard Hans, Chawes Bo L
Abstract excerpt
Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has been suggested, but the underlying mechanisms and characteristics of such an asthma endotype remain to be elucidated.Objectives: To study the sphingolipid-associated childhood asthma endotype using multiomic data.Methods: We used untargeted liquid chromatography-mass spectrometry plasma metabolomic profiles at the ages of 6...
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