Automatic cell type harmonization and integration across Human Cell Atlas datasets

Abstract excerpt

<h4>Summary</h4> Harmonizing cell types across the single-cell community and assembling them into a common framework is central to building a standardized Human Cell Atlas. Here we present CellHint, a predictive clustering tree-based tool to resolve cell type differences in annotation resolution and technical biases across datasets. CellHint accurately quantifies cell-cell transcriptomic similarities and places c...

Topics

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• Cancer Cells and Metastasis
• Neonatal Respiratory Health Research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

0ba537fe-dc9b-5aef-a9c9-9ffbb8dd6773

DOI

10.1101/2023.05.01.538994